Chemical Carcinogenesis and Mutagenesis I


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Low DNA repair is a risk factor in skin carcinogenesis: a study of basal cell carcinoma in psoriasis patients. Species differences in chemical carcinogenesis of the thyroid gland, kidney and urinary bladder. The multi-step nature of cancer development. Carcinogen adducts: use in diagnosis and risk assessment. Clin Chem Predictive toxicology: benchmarking molecular descriptors and statistical methods.

J Chem Inf Comput Sci Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex. Nat Genet The experimental study of tumor progression: a review. DNA damage and repair. Nature Hypothesis: chemical carcinogenesis mediated by a transiently active carcinogen receptor. Cytogenet Cell Genet Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics.

Drug Metabol Drug Interact Chemoprevention of gastrointestinal malignancies. ANZ J Surg The role of DNA adducts in chemical carcinogenesis. Relative potency of chemical carcinogens in rodents. Risk Anal 6: Carcinogenicity of azo colorants: influence of solubility and bioavailability. Environmental risk factors for gastric cancer: the toxicologist's standpoint. The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis. Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice. The cell cycle and chemical carcinogenesis.

Surv Synth Patho Res 1: Metabolism of chemical carcinogens. Forging the links between metabolism and carcinogenesis. Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J Biol Chem Diaz de Santos, Madrid, p. The hallmarks of cancer. Cell Functional characterization of global genomic DNA repair and its implications for cancer. The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms.

Environ Health Perspect Suppl 5 : Carcinogenesis bioassays: study duration and biological relevance. Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism. EMBO J Genetic susceptibility and occupational cancer. Med Lav The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol Chemical carcinogenesis. Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.

Recent Results Cancer Res Chemical toxicity and chemical carcinogenesis.


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Is there a causal connection? A comparative morphological evaluation of experiments. Chemicals causally associated with cancers in humans and in laboratory animals. A perfect concordance. Expression of the p48 xeroderma pigmentosum gene is pdependent and is involved in global genomic repair.

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Mutagenesis and transformation of normal cells by chemical carcinogens

Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies. Medium-term bioassays for carcinogens. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol Diverse chemical carcinogens fail to induce G 1 arrest in MCF-7 cells. Lack of pmediated G1 arrest in response to an environmental carcinogen. Oncology Genotoxicity in the rodent urinary bladder.


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Cancer-susceptibility genes. Gatekeepers and caretakers.

Chemical Carcinogens & Dna | Volume 2 | Taylor & Francis Group

Epigenetic mechanisms of chemical carcinogenesis. Hum Exp Toxicol Drinking water mutagenicity and gastrointestinal and urinary tract cancers: an ecological study in Finland. Am J Public Health The role of interindividual variation in human carcinogenesis. J Nutr SS. Prediction of genotoxicity of chemical compounds by statistical learning methods. Chem Res Toxicol Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid. Toxicology Cancer cells exhibit a mutator phenotype.

Adv Cancer Res Computer-assisted mechanistic structure-activity studies: application to diverse classes of chemical carcinogens. Nature and nurture - lessons from chemical carcinogenesis. Nat Rev Cancer 5: Dose-response relationships in chemical carcinogenesis: superposition of different mechanismsof action, resulting in linear-nonlinear curves, practical thresholds, J-shapes.

Dose-response relationships in chemical carcinogenesis reflect differences in individual susceptibility. Consequences for cancer risk assessment, extrapolation, and prevention. A true threshold dose in chemical carcinogenesis cannot be defined for a population, irrespective of the mode of action. Susceptibility differences in chemical carcinogenesis linearize the dose-response relationship: threshold doses can be defined only for individuals.

Differences in individual susceptibility to toxic effects of chemicals determine the dose-response relationship and consequences of setting exposure standards. A symposium summary and perspective on comparative molecular biology of cancer. Toxicol Pathol The contribution of the mouse in hazard identification studies.

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Human cancer cell lines: fact and fantasy. Nat Rev Mol Cell Biol 1: The potential for the use of cell proliferation and oncogene expression as intermediate markers during liver carcinogenesis.

CHEMICAL CARCINOGENESIS & Ames test

Cell proliferation and chemical carcinogenesis: symposium overview. Implications for risk assessment of suggested non-genotoxic mechanisms of chemical carcinogenesis. In vivo combinations between carcinogens and tissue constituints and theirpossible role in carcinogenesis. Metabolic activation and reactivity of chemical carcinogens.

Genetic variability in susceptibility and response to toxicants. K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers-a review. Cancer Detect Prev The role of cell proliferation in chemical carcinogenesis.

Relationship between schistosomiasis and bladder cancer. Clin Microbiol Rev Bull Acad Natl Med A ribonucleotide reductase gene is a transcriptional target of p53 and p Oncogene Epigenetic events during the process of cell transformation induced by carcinogens review. Oncol Rep 6: Metabolic detoxification: implications for thresholds. Chemical basis of inflammation-induced carcinogenesis. Arch Biochem Biophys Prevention of human cancer by modulation of chronicinflammatory processes. The role of metabolic activation in drug-induced hepatotoxicity.

Annu Rev Pharmacol Toxicol Animal models of neoplastic development. Dev Biol Basel Facts and theories concerning the mechanisms of carcinogenesis. Laser capture microdissection, microarrays and the precise definition of a cancer cell. Expert Rev Mol Diagn 4: Carcinogen macromolecular adducts and their measurement. Phenotypic diversity in experimental hepatomas: the concept of partially blocked ontogeny. The 10 Walter Hubert Lecture. Br J Cancer The role of transgenic mouse models in carcinogen identification.

Acquisition of apoptotic resistance in arsenic-induced malignant transformation: role of the JNK signal transduction pathway. Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis.

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Carcinogenesis 7: Pathologic basis of disease. How chemicals may induce cancer. Biomedicine Combination effects in chemical carcinogenesis experimental results. Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites.

Chemical Carcinogenesis and Mutagenesis I Chemical Carcinogenesis and Mutagenesis I
Chemical Carcinogenesis and Mutagenesis I Chemical Carcinogenesis and Mutagenesis I
Chemical Carcinogenesis and Mutagenesis I Chemical Carcinogenesis and Mutagenesis I
Chemical Carcinogenesis and Mutagenesis I Chemical Carcinogenesis and Mutagenesis I
Chemical Carcinogenesis and Mutagenesis I Chemical Carcinogenesis and Mutagenesis I
Chemical Carcinogenesis and Mutagenesis I Chemical Carcinogenesis and Mutagenesis I
Chemical Carcinogenesis and Mutagenesis I Chemical Carcinogenesis and Mutagenesis I

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